Protective Effects of Hong Shan Capsule against Lethal Total-Body Irradiation-Induced Damage in Wistar Rats.
MixedRadiationWistar rats; ICR miceMalen = 10 rats per group for rat survival; 11 to 12 mice per group…Intragastric2.5, 5 or 10 g crude drug/kg body weight/day dissolved in d…Pre-treatment for 3 consecutive days before irradiation; a separate mouse arm d…
Model: Acute lethal total-body irradiation from a cobalt-60 source at 2 Gy/min, delivering 6, 6.5 or 7 Gy to rats and 8 or 8.5 Gy to mice
Pre-treatment with 10 g/kg raised 30 day survival by 20% after 7 Gy (log rank p=0.0499) and after 6 Gy (p=0.0120) in rats and improved survival in mice after 8.5 Gy (p<0.0001), while post-irradiation dosing at 5 and 10 g/kg raised mouse 30 day survival by 9% and 18% (p=0.0014); ultrastructural dama…
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