THERAPY DOSSIER · th-af8291eedb2a

Hong Shan Capsule, a traditional Chinese medicine crude drug composed of 11 medicinal herbs

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26274957 ↗2015Reported benefit

Protective Effects of Hong Shan Capsule against Lethal Total-Body Irradiation-Induced Damage in Wistar Rats.

MixedRadiationWistar rats; ICR miceMalen = 10 rats per group for rat survival; 11 to 12 mice per group…Intragastric2.5, 5 or 10 g crude drug/kg body weight/day dissolved in d…Pre-treatment for 3 consecutive days before irradiation; a separate mouse arm d…

Model: Acute lethal total-body irradiation from a cobalt-60 source at 2 Gy/min, delivering 6, 6.5 or 7 Gy to rats and 8 or 8.5 Gy to mice

Pre-treatment with 10 g/kg raised 30 day survival by 20% after 7 Gy (log rank p=0.0499) and after 6 Gy (p=0.0120) in rats and improved survival in mice after 8.5 Gy (p<0.0001), while post-irradiation dosing at 5 and 10 g/kg raised mouse 30 day survival by 9% and 18% (p=0.0014); ultrastructural dama…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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