Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = Experiment I 34 rats (IRI plus saline 10, IRI plus ANP 10,…Intravenous infusion via the right femoral vein at 6 ml/kg/h0.2 microg/kg/minPost-treatment started 5 min after renal pedicle clamping in experiment I and 3…
Model: Renal ischaemia-reperfusion injury by clamping the left renal pedicle for 30 min with mechanical ventilation (experiment I) and by clamping both renal pedicles for 30 min without mechanical ventilation (experiment II), under pentobarbital anaesthesia
ANP post-treatment prevented ischaemia-reperfusion induced metabolic acidosis, pulmonary oedema and rises in lactate, creatinine and potassium, blocked the increase in TNF-alpha, IL-1beta and IL-6 mRNA in kidney and lung and IL-1beta and IL-6 in heart, and attenuated TNF-alpha, IL-6 and NF-kappaB l…
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