Prevention of acute kidney injury with human ANP in patients undergoing heart transplant
Acute Kidney Injury
Enrolment: 86 · Results not recorded
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Hormone · Atrial natriuretic peptide receptor agonist (AGONIST; direct interaction)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Kidney Injury
Enrolment: 86 · Results not recorded
Heart Failure · Renal Failure
Enrolment: 200 · Results not recorded
Heart Failure, Congestive · Heart Decompensation · Left Ventricular Failure · Myocardiopathies
Enrolment: 162 · Results not recorded
Respiratory Distress Syndrome
Enrolment not recorded · Results not recorded
Difficult to Control Hypertension
Enrolment: 120 · Results not recorded
Heart Failure · Hypertension · Kidney Failure
Enrolment: 17 · Results not recorded
Acute Myocardial Infarction
Enrolment: 600 · Results not recorded
Blood Pressure · Anesthesia
Enrolment: 24 · Results not recorded
Cardiovascular Diseases · Natriuretic Peptides · Obesity
Enrolment: 200 · Results not recorded
Obesity · Diabetes
Enrolment: 55 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Lipopolysaccharide-induced acute lung injury in mice and lipopolysaccharide-induced barrier disruption in human pulmonary endothelial cells
Lipopolysaccharide increased ANP and NPR-A expression; NPR-A inhibition augmented endothelial permeability and exacerbated lung injury in vivo, whereas NPR-C inhibition attenuated barrier disruption and reduced bronchoalveolar lavage cell count and protein content.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Renal ischaemia-reperfusion (60 min ischaemia, 24 h reperfusion)
hANP significantly attenuated the rise in serum BUN and creatinine and reduced histological kidney damage after renal ischaemia-reperfusion.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Renal ischaemia-reperfusion injury by clamping the left renal pedicle for 30 min with mechanical ventilation (experiment I) and by clamping both renal pedicles for 30 min without mechanical ventilation (experiment II), under pentobarbital anaesthesia
ANP post-treatment prevented ischaemia-reperfusion induced metabolic acidosis, pulmonary oedema and rises in lactate, creatinine and potassium, blocked the increase in TNF-alpha, IL-1beta and IL-6 mRNA in kidney and lung and IL-1beta and IL-6 in heart, and attenuated TNF-alpha, IL-6 and NF-kappaB l…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Acute lung injury and pulmonary oedema induced in anaesthetised mice by thrombin receptor agonist peptide or lipopolysaccharide, with in vitro thrombin-induced loss of transmembrane electrical resistance in pulmonary microvascular endothelial cell monolayers
Pretreatment with atrial natriuretic peptide completely blocked thrombin receptor agonist peptide induced increases in lung wet-to-dry weight and blunted lipopolysaccharide induced increases in lavage cell counts and protein in both NPR-A knockout and wild-type mice. The NPR-C specific ligand cANF…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.