Protective effect of N-acetylcysteine on cyclophosphamide-induced cardiotoxicity in rats.
RatChemical/toxinWistarMaleIntraperitoneal200 mg/kgPre-treatment for 5 days before cyclophosphamide administration
Model: Acute cardiotoxicity induced by a single intraperitoneal dose of cyclophosphamide 200 mg/kg
Cyclophosphamide raised serum aminotransferases, creatine kinase, lactate dehydrogenase, asymmetric dimethylarginine and TNF-alpha, lowered serum total nitrate/nitrite, and in cardiac tissue raised malondialdehyde and nitrate/nitrite while lowering reduced glutathione, glutathione peroxidase, catal…
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