Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.
MouseSpinal cord injuryUnspecifiedC57BL/6 (Mice, Inbred C57BL)Male and femaleAfter acute injury, exact timing not stated in the abstract
Model: Femoral nerve injury model and spinal cord injury model in mice, with supporting cell-based in vitro assays
L1 agonists stimulated neuronal survival, migration, neurite outgrowth, Schwann cell proliferation and migration and myelination in an L1-dependent manner in vitro; in vivo they enhanced functional regeneration and remyelination after femoral nerve injury and improved motor recovery after spinal co…
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