THERAPY DOSSIER · th-3174d1abf147

Eight small molecule L1 agonists identified by screening of known drug libraries, including duloxetine

Drug · Serotonin-noradrenaline reuptake inhibitor (SNRI); INHIBITOR at SLC6A4 and SLC6A2. ChEMBL match is for duloxetine, the only named member of the eight L1 agonists.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Serotonin-noradrenaline reuptake inhibitor (SNRI); INHIBITOR at SLC6A4 and SLC6A2. ChEMBL match is for duloxetine, the only named member of the eight L1 agonists.
Target: CHEMBL228; CHEMBL222
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 2004
Development stage: Not recorded
ChEMBL record: CHEMBL1175 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Duloxetine; LY-248686; Cymbalta; Xeristar; Yentreve
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00191932 ↗PHASE4completed

Switching to Duloxetine From Other Antidepressants: Multicentre Trial

Major Depressive Disorder

Enrolment: 360 · Results not recorded

NCT00433290 ↗PHASE3completed

Duloxetine 60 to 120 mg Versus Placebo in Osteoarthritis Knee Pain

Osteoarthritis Knee Pain

Enrolment: 256 · Results not recorded

NCT00489411 ↗PHASE3completed

Phase III Trial of Oral Duloxetine for Chemotherapy-Induced Peripheral Neuropathy Pain

Neurotoxicity · Pain · Peripheral Neuropathy

Enrolment: 231 · Results not recorded

NCT00767806 ↗PHASE3completed

Duloxetine 60 mg Once Daily Versus Placebo in Patients With Chronic Low Back Pain

Chronic Low Back Pain

Enrolment: 401 · Results not recorded

NCT01621191 ↗PHASE3completed

Open Label Extension Study of Phase 3 Trial of Duloxetine in Fibromyalgia

Fibromyalgia

Enrolment: 149 · Results not recorded

NCT05611749 ↗PHASE2terminated

Postoperative Duloxetine Impact on Pain Control Following Lateral Lumbar Interbody Fusion: RCT

Acute Post-operative Pain · Chronic Post Operative Pain · Opioid Use

Enrolment: 17 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26253722 ↗2015Reported benefit

Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.

MouseSpinal cord injuryUnspecifiedC57BL/6 (Mice, Inbred C57BL)Male and femaleAfter acute injury, exact timing not stated in the abstract

Model: Femoral nerve injury model and spinal cord injury model in mice, with supporting cell-based in vitro assays

L1 agonists stimulated neuronal survival, migration, neurite outgrowth, Schwann cell proliferation and migration and myelination in an L1-dependent manner in vitro; in vivo they enhanced functional regeneration and remyelination after femoral nerve injury and improved motor recovery after spinal co…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Loading the evidence…