Proline-Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing.
RatWoundSprague-DawleyMalen = 54 male rats in total (108 wounds, split-mouth), 18 animals…Topical application to the surgical wound bedEquimolar 37 microM final concentration for all peptides, e…At the time of surgery, immediately after haemostasis once the flap was raised
Model: Full-thickness mucoperiosteal flap (intracrevicular incision around upper first molar extended to palatal mucosa) creating an incisional wound on the palatal mucosa, split-mouth design with two wounds per animal
At day 1 wound closure was 75 plus or minus 3.8 per cent for EMD and 51 plus or minus 3.7 per cent for P2 versus 43 plus or minus 2 per cent for control and 44.8 plus or minus 3.4 per cent for TRAP; odds of wound closure rose 28 per cent with EMD (p less than 0.0001) and 12 per cent with P2 (p = 0.…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.