THERAPY DOSSIER · th-58fd89bb293c

Enamel matrix derivative (EMD, Emdogain), recombinant tyrosine-rich amelogenin peptide (TRAP) and synthetic proline-rich polypeptide P2

Biologic · Biologic (enamel matrix proteins; not a discrete ChEMBL small molecule); periodontal regeneration

Evidence & regulatory context

Mechanism: Biologic (enamel matrix proteins; not a discrete ChEMBL small molecule); periodontal regeneration
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06725095 ↗NAenrolling by invitation

Enamel Matrix Derivative in Non-surgical Treatment of Peri-implant Mucositis

Peri Implant Mucositis

Enrolment: 54 · Results not recorded

NCT07589959 ↗NAnot yet recruiting

Polynucleotides/Hyaluronic Acid vs Enamel Matrix Derivative in Intrabony Defects

Periodontal Defect

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26252748 ↗2015Mixed findings

Proline-Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing.

RatWoundSprague-DawleyMalen = 54 male rats in total (108 wounds, split-mouth), 18 animals…Topical application to the surgical wound bedEquimolar 37 microM final concentration for all peptides, e…At the time of surgery, immediately after haemostasis once the flap was raised

Model: Full-thickness mucoperiosteal flap (intracrevicular incision around upper first molar extended to palatal mucosa) creating an incisional wound on the palatal mucosa, split-mouth design with two wounds per animal

At day 1 wound closure was 75 plus or minus 3.8 per cent for EMD and 51 plus or minus 3.7 per cent for P2 versus 43 plus or minus 2 per cent for control and 44.8 plus or minus 3.4 per cent for TRAP; odds of wound closure rose 28 per cent with EMD (p less than 0.0001) and 12 per cent with P2 (p = 0.…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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