Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing, and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury.
RatTBIControlled cortical impactSprague-DawleyMaleOral, dietary (DHA-enriched diet given to the dam and then to the pups)DHA introduced into the dam diet the day before CCI to allow timely delivery to…
Model: Controlled cortical impact (CCI) in the immature rat pup, with sham surgery controls
DHA did not adversely affect survival or weight gain; it acutely decreased oxidative stress and increased anti-inflammatory interleukin 10 in CCI brains, improved Morris water maze performance and lesion volume late after injury, and at post-injury day 12 decreased T2-imaging measures of cerebral o…
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