Neuregulin-1 protects against acute optic nerve injury in rat model.
RatOtherSprague-DawleyMalen = 48 rats in the expression experiment (sham-operation n=24,…0.5 microgram, 1 microgram and 3 micrograms of recombinant…
Model: Surgically induced acute optic nerve injury with sham-operation controls; outcomes followed at 2 h, 1 d, 2 d, 7 d, 14 d and 28 d
Endogenous NRG-1 expression rose after injury, peaking at 14 d and declining by 28 d. Treatment with 1 microgram and 3 micrograms of recombinant human NRG-1 gave significantly better FVEP-P100 amplitudes than normal saline (all P<0.05), and ganglion cell apoptosis was markedly reduced in NRG-1 trea…
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