Zearalenone-induced changes in biochemical parameters, oxidative stress and apoptosis in cardiac tissue: Protective role of crocin.
MouseChemical/toxinBalb/cCrocin 50, 100 and 250 mg/kg body weight; zearalenone 40 mg…Co-administered with zearalenone as combined treatment
Model: Acute zearalenone-induced cardiotoxicity, with zearalenone administered at 40 mg/kg body weight
Zearalenone raised cardiac injury enzymes and lipids, induced oxidative stress and Hsp70 expression, and triggered apoptosis in cardiac tissue. Combined treatment with crocin at 50, 100 and 250 mg/kg produced a significant, dose-dependent reduction of zearalenone-induced toxicity across all tested…
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