Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity.
RatChemical/toxinWistarMaleCoadministered with cisplatin
Model: Cisplatin-induced acute kidney injury, assessed four days after cisplatin administration
Cisplatin alone raised plasma urea and creatinine and caused tubular damage, with a marked increase in urinary excretion of exosomal Oat5. With N-acetylcysteine coadministration, plasma urea and creatinine tended to return towards basal values, tubular damage was improved, and the rise in exosomal…
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