Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1beta-TNFalpha Signaling
MixedChemical/toxinICRMalen = Six mice per group across five groups (30 mice) for each in…Oral gavage (in vivo); medium addition (in vitro)75, 150 or 300 mg/kg in vivo; 2 microg/ml (5.95 micromol/L)…Pretreatment 1 hour before alcohol administration
Model: Acute heavy alcohol exposure by single oral gavage of 60% (v/v) alcohol at 15 ml/kg (approximately 7.103 g/kg), causing gastric and small intestinal mucosal injury; parallel in vitro alcohol exposure of Caco2 cells at 348 mmol/L
Berberine dose dependently prevented alcohol-induced congestion, oedema and necrosis of the duodenal mucosa (highest dose 300 mg/kg most effective, Kruskal-Wallis chi-squared 24.07, p = 7.735e-05 for injury score), lowered blood alcohol concentration even at lower doses, raised plasma ADH activity…
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