Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2
MouseOtherC57BL/6JBoth male and female (either gender)n = 36 mice total; 32 randomised to four groups of n = 8 (non-s…Inhalational via tracheal intubation and mechanical ventilationFiO2 1.0 versus FiO2 0.21; tidal volume 8 microL/g, respira…Started immediately after blast wave-induced chest trauma
Model: Single blast wave centred on the mid-sternal chest producing blunt chest trauma with lung contusion, in mice with or without 3 to 4 weeks of prior cigarette smoke exposure
Prior cigarette smoke exposure worsened post-traumatic injury, with higher compliance, lower PaO2 and Horovitz index (491 versus 368 mmHg), raised lung IL-18 (603 versus 973 pg/mg protein, p = 0.019), two to four-fold greater inflammatory cell infiltration, thicker alveolar membranes, more activate…
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