THERAPY DOSSIER · th-e465e491452f

Pressure-controlled lung-protective mechanical ventilation with 100% oxygen

Procedure · Procedure (mechanical ventilation strategy); not a ChEMBL entity; the specific 100% oxygen protocol not identified in trials

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Procedure (mechanical ventilation strategy); not a ChEMBL entity; the specific 100% oxygen protocol not identified in trials
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26225825 ↗2015Mixed findings

Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2

MouseOtherC57BL/6JBoth male and female (either gender)n = 36 mice total; 32 randomised to four groups of n = 8 (non-s…Inhalational via tracheal intubation and mechanical ventilationFiO2 1.0 versus FiO2 0.21; tidal volume 8 microL/g, respira…Started immediately after blast wave-induced chest trauma

Model: Single blast wave centred on the mid-sternal chest producing blunt chest trauma with lung contusion, in mice with or without 3 to 4 weeks of prior cigarette smoke exposure

Prior cigarette smoke exposure worsened post-traumatic injury, with higher compliance, lower PaO2 and Horovitz index (491 versus 368 mmHg), raised lung IL-18 (603 versus 973 pg/mg protein, p = 0.019), two to four-fold greater inflammatory cell infiltration, thicker alveolar membranes, more activate…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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