CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice

CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice

Model: Total-body irradiation from a 60Co source at 7.2 and 8.5 Gy delivered at a dose rate of 0.04 Gy per minute, producing acute radiation syndrome

Prophylactic CCM-Ami gave both a survival benefit and haematopoietic protection relative to excipient control and free amifostine after 7.2 and 8.5 Gy total-body irradiation, and plasma concentrations of the active metabolite WR-1065 were higher in CCM-Ami treated than amifostine treated mice, indi…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.