Angiopreventive versus angiopromoting effects of allopurinol in the murine sponge model.
MouseOtherC57BL/6MaleOral gavage1.0 mg/kgTwo regimens: treatment started 24 h after sponge implantation (acute phase) or…
Model: Subcutaneous implantation of polyether-polyurethane sponge discs to induce inflammatory angiogenesis and fibrovascular tissue formation
When started 24 h after implantation, allopurinol reduced angiogenesis (haemoglobin, VEGF, vessel number), inflammatory markers (MPO, NAG, TNF-alpha, CCL2) and nitric oxide and H2O2 production, while increasing collagen deposition and TGF-beta1. When started during the chronic inflammatory phase (d…
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