Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress.
Model: Unilateral lung contusion created with a percussive nail gun, alone or followed by haemorrhagic shock (blood withdrawal to a mean arterial pressure of 30-35 mmHg maintained for 45 min then reinfusion of shed blood), combined with six days of chronic restraint stress (daily 2 h restraint interrupted every 30 min by alarms and repositioning)
Adding chronic restraint stress to lung contusion and lung contusion with haemorrhagic shock significantly prolonged HPC mobilisation at day 7 with persistently raised G-CSF and worse lung injury scores. Daily propranolol reduced peripheral HPC to near naive levels (LC/CRS+Prop 0.7 +/- 0.2 % vs LC/…
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