Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids.
MouseSpinal cord injuryCompressionMaleProlonged post-traumatic treatment, with mice sacrificed seven days after induc…
Model: Experimental spinal cord injury in mice induced by compression, with a parallel in vitro model of LPS-induced inflammation in J774 macrophage cells
All three glucocorticoids modulated inflammatory, oxidative and apoptotic pathways after compression spinal cord injury, but mometasone furoate was more potent than dexamethasone and methylprednisolone sodium succinate in both the in vitro LPS model and the in vivo injury model, with dexamethasone…
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