A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.
Model: Unilateral (hemicord) contusion of the lower cervical spinal cord at C7, produced under ketamine/xylazine anaesthesia by releasing a 10 g weight from a height of 25 mm onto a 1.55 mm diameter impactor positioned on the dura near the left C8 nerve root, producing ipsilateral but not contralateral primary haemorrhage
Treatment-associated mortality was 30% (3/10) control, 30% (3/10) riluzole, 12.5% (1/8) hypothermia and 0% (0/7) glibenclamide. All three treatments improved mBBB scores versus control during the last four weeks; riluzole-treated rats underperformed for the first two weeks. On beam balance, hypothe…
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