Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/6MaleIntravenous1 mg/kg dailyAdministered after controlled cortical impact injury; exact start time not stat…
Model: Controlled cortical impact (CCI) traumatic brain injury in mice, with assessment of blood-brain barrier dysfunction and vasogenic oedema at an acute stage
COG1410 suppressed matrix metalloproteinase-9 activity, reduced blood-brain barrier disruption and Evans Blue dye extravasation, reduced lesion volume and vasogenic oedema, and decreased functional deficits compared with vehicle-treated mice at an acute stage after controlled cortical impact. The a…
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