A Proof of Concept Study to Evaluate Administration of CN-105 in Patients With Acute Supratentorial Intracerebral Hemorrhage
Intracerebral Hemorrhage
Enrolment: 38 · Results not recorded
Loading the evidence…
Biologic · ChEMBL compound_search for 'COG1410' returned 0 records (explicit negative result). COG1410 is a 12-mer ApoE-mimetic peptide with no ChEMBL entity. CLASS-LEVEL / TRANSLATIONAL-ANALOGUE FLAG: no human trial administers COG1410 itself. The 5 recorded trials are the closest clinical analogues, 4 of them CN-105, a 5-mer ApoE-mimetic pentapeptide from the same Duke lineage as COG1410 and the only ApoE-mimetic to reach neurological injury indications (intracerebral haemorrhage, postoperative delirium/cognitive dysfunction). NCT02100839 AEM-28 is a structurally different ApoE-mimetic developed for hypercholesterolaemia, recorded at class level only and NOT a neuroprotection analogue.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intracerebral Hemorrhage
Enrolment: 38 · Results not recorded
Intracerebral Hemorrhage
Enrolment: 240 · Results not recorded
Intracerebral Hemorrhage (ICH)
Enrolment: 48 · Results not recorded
Postoperative Delirium · Postoperative Cognitive Dysfunction
Enrolment: 203 · Results not recorded
Hypercholesterolemia · Hyperlipoproteinemia Type II
Enrolment: 52 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Controlled cortical impact (CCI) traumatic brain injury in mice, with assessment of blood-brain barrier dysfunction and vasogenic oedema at an acute stage
COG1410 suppressed matrix metalloproteinase-9 activity, reduced blood-brain barrier disruption and Evans Blue dye extravasation, reduced lesion volume and vasogenic oedema, and decreased functional deficits compared with vehicle-treated mice at an acute stage after controlled cortical impact. The a…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.