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PRECLINICAL PUBLICATION · 2015

Rosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitis.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 26191125 ↗2015Reported benefit

Rosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitis.

RatOtherSprague-DawleyMale

Model: Hyperlipidaemic pancreatitis with associated acute renal injury in rats; induction method not stated in the available text

Rosiglitazone inhibited activation of the NF-kappaB and MAPK p38 signalling pathways, relieved the inflammatory response and inhibited cell apoptosis, thereby attenuating renal injury caused by hyperlipidaemic pancreatitis. The authors suggest rosiglitazone may be a promising drug for treating rena…

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