Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions.
RatWoundSprague-Dawley (in vivo corneal wound healing experiments)MaleAdded to culture medium in vitro; topical application to the cornea in vivo10 microM dimethylfumarate or carnosol in cell culture; top…
Model: Corneal epithelial injury model in diabetic rats treated topically, together with an in vitro scratch wound assay in human retinal pigment epithelial (ARPE-19) cells cultured in medium containing normal (5 mM) or high (25 mM) glucose
Nrf2 nuclear translocation and heme oxygenase activity increased in ARPE-19 cells treated with 10 microM dimethylfumarate or carnosol irrespective of glucose concentration. High glucose reduced cellular and mitochondrial reactive oxygen species, reduced ATP production and mitochondrial function, an…
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