Rapid creation of skin substitutes from human skin cells and biomimetic nanofibers for acute full-thickness wound repair.
MouseWoundAthymic nude (Ncr Nude)n = 40 nude mice in total; n = 5 per group at each of the day 1…Topical grafting onto the wound bed, fixed with corner stitches and dressed with Adaptic, antibiotic-moistened gauze, Opsite IV3000 and elastic bandage15-layer construct (10 alternating fibroblast/nanofiber lay…Grafted immediately after creation of the full-thickness wound
Model: Surgically created square full-thickness excisional wound (1.0 x 1.0 cm) on the back of nude mice
Two-week cultured skin substitutes reached an ultimate tensile stress of 3.9 plus or minus 0.4 MPa and strain of 150 plus or minus 27%. By day 10, skin substitute-treated wounds showed more than 40% re-epithelialisation versus 11 plus or minus 5% for acellular meshes and 20 plus or minus 3% for der…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.