Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Wound
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 7
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
A Phase II Study to Evaluate an Autologous Bio-engineered Dermo-epidermal Skin Substitute (EHSG-KF) for Full-Thickness Defects vs Split-thickness Skin Grafts
Skin Wound
Enrolment: 20 · Results not recorded
A Phase IIb Study of an Autologous Bio-engineered Dermo-epidermal Skin Substitute (EHSG-KF) for Partial Deep Dermal and Full Thickness Burns in Children
Burns
Enrolment: 12 · Results not recorded
A Phase IIb Study of an Autologous Bio-engineered Dermo-epidermal Skin Substitute (EHSG-KF) for Partial Deep Dermal and Full Thickness Burns in Adults and Adolescents
Burns
Enrolment: 14 · Results not recorded
A Phase I Study to Evaluate the Safety of Autologous Tissue-engineered Dermal Substitutes and Dermo-epidermal Skin Substitutes for Large Deep Partial and Full Thickness Skin Defects
Burn Injury · Soft Tissue Injury · Skin Necrosis · Scars · Congenital Giant Nevus · Skin Tumors
Enrolment: 12 · Results not recorded
Phase II Clinical Trial Evaluating the Safety and Efficacy of a Tissue Engineered Autologous Skin Substitute Reconstructive Surgery for Basal Cell Carcinoma
Basal Cell Carcinoma
Enrolment: 21 · Results not recorded
Treatment of Cutaneous Ulcers With a Novel Biological Dressing (self assembled skin substitute)
Venous Ulcers
Enrolment: 6 · Results not recorded
A Randomized Multi-Center Comparative Study of Amniotic Membrane Wound Graft Versus Tissue Engineered Skin Substitute in Non Healing Diabetic Foot Ulcers
Diabetic Foot Ulcer
Enrolment: 60 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseWoundAthymic nude (Ncr Nude)n = 40 nude mice in total; n = 5 per group at each of the day 1…Topical grafting onto the wound bed, fixed with corner stitches and dressed with Adaptic, antibiotic-moistened gauze, Opsite IV3000 and elastic bandage15-layer construct (10 alternating fibroblast/nanofiber lay…Grafted immediately after creation of the full-thickness wound
Model: Surgically created square full-thickness excisional wound (1.0 x 1.0 cm) on the back of nude mice
Two-week cultured skin substitutes reached an ultimate tensile stress of 3.9 plus or minus 0.4 MPa and strain of 150 plus or minus 27%. By day 10, skin substitute-treated wounds showed more than 40% re-epithelialisation versus 11 plus or minus 5% for acellular meshes and 20 plus or minus 3% for der…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
