Retina Is Protected by Neuroserpin from Ischemic/Reperfusion-Induced Injury Independent of Tissue-Type Plasminogen Activator.
MouseIschaemia-reperfusionOther / unspecifiedC57BL/6 wild type and tissue-type plasminogen activator deficient (tPA-/-)Malen = 98 male mice in total (62 wild type, 36 tPA-/-); electroret…Intravitreal injection1 microlitre of 20 micromolar neuroserpin intravitreally, i…Immediately before induction of ischaemia/reperfusion injury (pretreatment)
Model: Retinal ischaemia/reperfusion induced by cannulating the anterior chamber of the right eye and raising intraocular pressure to 120 mmHg for 60 minutes followed by reperfusion, with the left eye as uninjured control
Neuroserpin pretreatment did not change the acute 24 hour loss of a- and b-waves but produced significantly greater b-wave recovery at 7 days in both wild type (p = 0.02) and tPA-/- mice (p = 0.01). TUNEL-positive cells at 24 hours fell from 25.33 plus or minus 3.21 to 6.67 plus or minus 1.15 per f…
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