Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntravenous (GSNO and FeTPPS); intraperitoneal (7-nitroindazole, AICAR, compound c)GSNO 0.25 mg/kg; comparator agents 7-nitroindazole 50 mg/kg…GSNO and 7-nitroindazole given at reperfusion (0 h); AICAR, compound c and FeTP…
Model: Transient focal cerebral ischaemia by 60 min left middle cerebral artery occlusion with intraluminal filament, followed by reperfusion
GSNO reduced nNOS activity and neuronal peroxynitrite, increased nitric oxide bioavailability, preserved neuronal and axonal integrity, reduced infarct volume and improved neurological score. GSNO reduced infarct volume more than 7-nitroindazole and, unlike 7-nitroindazole, significantly improved n…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.