Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury · Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatSpinal cord injuryContusionSprague-DawleyMalen = 21 rats, 7 per group (injury, injury plus GSNO, sham)Intravenous0.05 mg/kg body weight (50 micrograms/kg) in about 25 micro…First dose at 2 h after injury
Model: Contusion spinal cord injury at T9-T10 by computer-controlled impactor, 2 mm tissue deformation, impact velocity 1.5 m/s, contusion time 85 ms; 2-week model
GSNO significantly improved locomotor recovery by day 14 and raised the mechanical withdrawal threshold from day 7 onwards, while significantly reducing 3-nitrotyrosine, nNOS phosphorylation and calpain-derived alpha II spectrin breakdown product 145 kDa relative to untreated injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntravenous (GSNO and FeTPPS); intraperitoneal (7-nitroindazole, AICAR, compound c)GSNO 0.25 mg/kg; comparator agents 7-nitroindazole 50 mg/kg…GSNO and 7-nitroindazole given at reperfusion (0 h); AICAR, compound c and FeTP…
Model: Transient focal cerebral ischaemia by 60 min left middle cerebral artery occlusion with intraluminal filament, followed by reperfusion
GSNO reduced nNOS activity and neuronal peroxynitrite, increased nitric oxide bioavailability, preserved neuronal and axonal integrity, reduced infarct volume and improved neurological score. GSNO reduced infarct volume more than 7-nitroindazole and, unlike 7-nitroindazole, significantly improved n…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
