Effect of corticosteroid treatment on cell recovery by lung lavage in acute radiation-induced lung injury.
RatRadiationFemaleIntraperitoneal7.5 mg/kg per weekAfter thoracic irradiation, continuing for up to 6 weeks
Model: Thoracic irradiation, 24 Gy
Irradiation increased total lavage cells from 3 weeks, initially neutrophils then macrophages. At 6 weeks methylprednisolone-treated irradiated rats had significantly fewer total cells, macrophages, neutrophils and lymphocytes than saline-treated irradiated rats, indicating suppression of the acute…
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