Biliary tract external drainage alleviates kidney injury in shock.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 36 rats randomised across six groupsSurgical insertion of a catheter into the bile duct
Model: Haemorrhagic shock induced by blood withdrawal from the femoral artery, with acute kidney injury
Biliary tract external drainage markedly increased renal occludin mRNA and protein and significantly reduced renal histopathology scores under haemorrhagic shock. Zinc protoporphyrin IX abolished these effects, implicating the haem oxygenase-1 pathway.
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