Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo.
MixedChemical/toxinResveratrol to quercetin to doxorubicin ratio of 10:10:1; m…Co-administered concurrently with doxorubicin
Model: Acute doxorubicin hydrochloride-induced cardiotoxicity in healthy mice
The 10:10:1 resveratrol:quercetin:doxorubicin combination was synergistic in ovarian cancer cells and antagonistic in cardiomyocytes, scavenging reactive oxygen species and reducing caspase 3/7 activity only in cardiomyocytes. In mice, co-administration of the micelles with acute doxorubicin confer…
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