Cholecalciferol (vitamin D3) improves functional recovery when delivered during the acute phase after a spinal cord trauma.
RatSpinal cord injuryHemisection / partialSprague-DawleyMaleOral500 IU/kg/dayTreatment started on day 1 or day 7 after injury
Model: Left cervical (C2) spinal cord hemisection
Vitamin D3-treated animals showed enhanced locomotor activity, improved ventilatory response to induced hindlimb muscle fatigue, H-reflex depression comparable with controls and a preserved phrenic nerve response to asphyxial stress. The reduction in axon number in the proximal stump versus sham wa…
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