Elevation of miR-21, through targeting MKK3, may be involved in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
MixedIschaemia-reperfusionRenalC57BL/6JMalePreconditioning applied before the ischaemia-reperfusion insult
Model: Renal ischaemia-reperfusion with ischaemic preconditioning
Ischaemic preconditioning raised miR-21 ahead of ischaemia-reperfusion and inhibited the rises in MKK3, IL-6 and TNF-alpha as well as the increases in serum creatinine, blood urea nitrogen and histological injury. miR-21 was confirmed to target MKK3 via its 3' untranslated region.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.