Remote Ischaemic Preconditioning in Cardiac Surgery With Cardiopulmonary Bypass in Children
Ischaemic Reperfusion Injury
Enrolment: 51 · Results not recorded
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Procedure
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Ischaemic Reperfusion Injury
Enrolment: 51 · Results not recorded
Elective Aortic Valve Replacement
Enrolment: 79 · Results not recorded
Low Back Pain · Knee Osteoarthritis
Enrolment: 24 · Results not recorded
Hypertension
Enrolment: 400 · Results not recorded
Myocardial Infarction
Enrolment: 220 · Results not recorded
Ischemic Stroke
Enrolment: 910 · Results not recorded
Peripheral Arterial Disease
Enrolment: 42 · Results not recorded
Carotid Stenosis
Enrolment: 86 · Results not recorded
Brain Aneurysms
Enrolment: 26 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Renal ischaemia-reperfusion with ischaemic preconditioning
Ischaemic preconditioning raised miR-21 ahead of ischaemia-reperfusion and inhibited the rises in MKK3, IL-6 and TNF-alpha as well as the increases in serum creatinine, blood urea nitrogen and histological injury. miR-21 was confirmed to target MKK3 via its 3' untranslated region.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Superior mesenteric artery occlusion for 45 min followed by 120 min of reperfusion (intestinal ischaemia-reperfusion)
Preconditioning reduced granulocyte count and plateletcrit and increased lymphocyte count and mean platelet volume relative to ischaemia-reperfusion alone, and restored mean corpuscular haemoglobin concentration, suggesting attenuation of the circulating cell response to intestinal ischaemia-reperf…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: In-situ submandibular gland ischaemia/reperfusion without denervation (90 min ischaemia followed by 1, 12, 24 or 72 h reperfusion)
Ischaemia/reperfusion produced acute inflammation, reduced tight junction width, and increased myeloperoxidase activity, reactive oxygen species and apoptotic cell numbers with secretory dysfunction, most marked at 1 and 12 h post-reperfusion and largely normalising by 72 h. Ischaemic preconditioni…
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Model: Acute kidney injury induced by clamping the left renal artery and vein for 45 minutes followed by reperfusion, 2 weeks after contralateral nephrectomy
Ischaemic preconditioning suppressed renal sympathetic nerve activity and noradrenaline release and attenuated renal dysfunction and histological damage, an effect abolished by non-selective nitric oxide synthase inhibition.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.