Comparison of the protective roles of L-carnitine and amifostine against radiation-induced acute ovarian damage by histopathological and biochemical methods.
RatRadiationWistar albinoFemalen = 45 rats in six groups (n = 7 or 8 per group)IntraperitonealL-carnitine 300 mg/kg; amifostine 200 mg/kg30 minutes before irradiation
Model: Single 20 Gy whole-abdomen irradiation causing acute ovarian damage
Irradiation reduced antral follicles and corpora lutea and raised malondialdehyde and advanced oxidation protein products. L-carnitine increased both antral follicle and corpus luteum counts, whereas amifostine improved corpus luteum counts only. Both agents significantly reduced malondialdehyde an…
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