Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma.
MouseFractureFemurC57BL/6Malen = At least 5 mice per group and time point; reported group si…Inhalation100% inspired oxygen delivered in chambers with constant ox…Started immediately after surgery and thoracic trauma
Model: Right femoral midshaft osteotomy (0.4 mm gap) stabilised with an external fixator, alone or combined with blunt thoracic trauma delivered by a single blast wave 2 cm above the thorax
Thoracic trauma raised plasma IL-6, IL-10 and MCP-1 at 3 h, increased pulmonary neutrophil influx and lung IL-1beta, IL-6 and IL-10, and reduced bending stiffness (-46%), moment of inertia (-33%) and apparent Young's modulus (-43%) at 21 days with more residual cartilage at 14 days. Two 3 hour expo…
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