THERAPY DOSSIER · th-c86470406000

100% oxygen (short-term normobaric hyperoxia)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Fracture
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05965687 ↗PHASE3completed

Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)

Acute Ischemic Stroke

Enrolment: 1230 · Results not recorded

NCT04681651 ↗PHASE2completed

Normobaric Hyperoxia for Acute Ischemic Stroke Patients Undergoing Endovascular Treatment

Acute Ischemic Stroke

Enrolment: 282 · Results not recorded

NCT06224426 ↗NArecruiting

Oxygenation Targets for Endovascular Therapy in Acute Ischemic Stroke (Oxy-TARGET)

Ischemic Stroke

Enrolment: 200 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26147725 ↗2015Reported benefit

Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma.

MouseFractureFemurC57BL/6Malen = At least 5 mice per group and time point; reported group si…Inhalation100% inspired oxygen delivered in chambers with constant ox…Started immediately after surgery and thoracic trauma

Model: Right femoral midshaft osteotomy (0.4 mm gap) stabilised with an external fixator, alone or combined with blunt thoracic trauma delivered by a single blast wave 2 cm above the thorax

Thoracic trauma raised plasma IL-6, IL-10 and MCP-1 at 3 h, increased pulmonary neutrophil influx and lung IL-1beta, IL-6 and IL-10, and reduced bending stiffness (-46%), moment of inertia (-33%) and apparent Young's modulus (-43%) at 21 days with more residual cartilage at 14 days. Two 3 hour expo…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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