The ameliorative effect of silibinin against radiation-induced lung injury: protection of normal tissue without decreasing therapeutic efficacy in lung cancer.
MouseRadiationC57BL/6Femalen = 10 mice per treatment group for the survival analysis; at l…Oral100 mg/kg/dayStarted immediately after irradiation
Model: Whole-thorax irradiation with a single 13 Gy dose of 6 MV photons at 3.8 Gy/min, with a separate arm in mice bearing intravenously seeded Lewis lung carcinoma nodules
All irradiated mice survived to 170 days but survival fell to 40 per cent by 200 days, whereas all silibinin-treated irradiated mice survived to 200 days. Silibinin reduced bronchoalveolar lavage inflammatory cells, macrophage enlargement and collagen deposition, and did not reduce the antitumour e…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.