Beneficial Effects of Early mTORC1 Inhibition after Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/61 h after controlled cortical impact
Model: Moderate controlled cortical impact
A single rapamycin injection 1 h after controlled cortical impact suppressed the early neuronal peak of mTORC1 activity and significantly reduced neuronal death, astrogliosis and cognitive impairment at 1 to 3 days after injury.
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