Comparison of the effect of topical versus systemic L-arginine on wound healing in acute incisional diabetic rat model.
RatWoundSprague-DawleyMalen = 56 rats in 7 groups of 8 (32 rendered diabetic)Oral gavage (systemic arm) and topical application to the wound (topical arm)Systemic 1 g/kg twice daily in 1 ml water; topical 1 cc of…
Model: Rectangular 1.5 cm x 1 cm dorsal skin wound excised to the level of the panniculus carnosus, in streptozotocin-induced diabetic and normoglycaemic rats
Systemic L-arginine produced significantly higher wound fluid nitrite than topical L-arginine and a significantly better histological healing score in diabetic rats; VEGF corrected for total protein was raised in all L-arginine treated groups relative to controls.
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