Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo.

PMID 26091318 ↗2015Reported benefit

Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo.

MouseTBIControlled cortical impactCD1Malen = 38 mice in total: sham plus vehicle 9, sham plus enoxaparin…Subcutaneous1 mg/kgFirst dose 2 h after injury

Model: Controlled cortical impact traumatic brain injury through a left-sided 4 mm craniotomy, using a 3 mm impactor tip at 6 m/s velocity and 1 mm cortical deformation

Enoxaparin reduced leukocyte rolling from 72.7 (SD 28.3) to 30.6 (SD 18.3) leukocytes per 100 micrometres per minute (p = 0.02) and albumin leakage from 34.5 to 23.8 per cent (p = 0.047), reduced ipsilateral hemispheric water content (81.5 to 77.6 per cent, p less than 0.01) and improved Neurologic…

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Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo.

Evidence by therapy association

Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo.