Mesenchymal stem cells increase T-regulatory cells and improve healing following trauma and hemorrhagic shock.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 5 to 6 rats per groupIntravenous, given into the jugular vein over five minutesSingle dose of 5 x 10 cells in 1 mL IMDM; the exponent digi…Within ten minutes of completion of resuscitation, after return of shed blood
Model: Unilateral lung contusion induced by a percussive nail gun blast wave against a 12 mm metal plate, followed by haemorrhagic shock with mean arterial pressure held at 30 to 35 mmHg for 45 min and then reinfusion of shed blood
Lung Injury Score at 7 days was 0.8 (SD 0.4) after contusion alone, 3.7 (SD 0.81) after contusion plus haemorrhagic shock and 1.6 (SD 0.6) with mesenchymal stem cells (p less than 0.05 versus contusion plus shock), driven by lower oedema subscores. Peripheral regulatory T cells rose from 9.3 to 18.…
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