Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury.
RatOtherSprague-DawleyMalen = 36 rats in three groups of 12Intraperitoneal5 mL/kg of saline saturated to a hydrogen concentration of…30 min after injury
Model: Smoke inhalation injury in a combustion and traumatogenic chamber with carbon monoxide held at 600 ppm, using a 2-5-2-5-2 min smoke and fresh air exposure pattern
Hydrogen-rich saline significantly reduced tumour necrosis factor alpha, malondialdehyde, NF-kappaB p65 expression and apoptosis index and increased superoxide dismutase activity compared with saline-treated injured rats (p less than 0.05), with improved alveolar structure. Exact means were not rep…
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