Hydrotherapy With Hydrogen-rich Water Compared With RICE Protocol Following Acute Ankle Sprain
Ankle Injuries
Enrolment: 18 · Results not recorded
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Drug
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Ankle Injuries
Enrolment: 18 · Results not recorded
Autoimmune Diseases
Enrolment: 27 · Results not recorded
Mucositis Oral
Enrolment: 24 · Results not recorded
Obesity
Enrolment: 36 · Results not recorded
Premenstrual Syndrome
Enrolment: 72 · Results not recorded
Type 2 Diabetes
Enrolment: 96 · Results not recorded
Cardiovascular Diseases · Hypertension · Blood Pressure
Enrolment: 52 · Results not recorded
Metabolic Syndrome
Enrolment: 40 · Results not recorded
Healthy Subjects or Volunteers
Enrolment: 24 · Results not recorded
Body Composition · Insulin Sensitivity · Oxidative Stress · Inflammation
Enrolment: 60 · Results not recorded
10 studies reported at therapy level; 10 evidence entries itemised.
Model: Hyperoxia-induced acute lung injury
Hydrogen-rich saline reduced oxidative damage, oedema, apoptosis and inflammation in hyperoxic lung injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: 30% TBSA full-thickness burn with delayed resuscitation
Hydrogen-rich saline improved pulmonary function and reduced oxidative and inflammatory markers in burn-induced acute lung injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Smoke inhalation injury in a combustion and traumatogenic chamber with carbon monoxide held at 600 ppm, using a 2-5-2-5-2 min smoke and fresh air exposure pattern
Hydrogen-rich saline significantly reduced tumour necrosis factor alpha, malondialdehyde, NF-kappaB p65 expression and apoptosis index and increased superoxide dismutase activity compared with saline-treated injured rats (p less than 0.05), with improved alveolar structure. Exact means were not rep…
Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Full-thickness scald burn of 40% total body surface area produced by immersing the shaved back in 100 degrees C water for 15 s under sodium pentobarbital anaesthesia (50 mg/kg intraperitoneally), with early acute kidney injury assessed at 6, 24 and 72 h
Hydrogen-rich saline improved renal function and reduced tubular apoptosis, markedly lowered oxidation-reduction potential and malondialdehyde, raised endogenous antioxidant enzyme activities, decreased myeloperoxidase and inflammatory mediator release, inhibited p38, JNK, ERK and NF-kappaB activat…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by retrograde pancreatic duct infusion of sodium taurocholate, with secondary acute kidney injury
Hydrogen-rich saline lowered serum creatinine and BUN, reduced pancreatic and renal histological injury, lowered renal MDA and MPO, reduced serum IL-1beta and IL-6 and renal TNF-alpha and HMGB1, and reduced tyrosine nitration, IkappaB degradation and NF-kappaB activation, while increasing renal IL-…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Unilateral ureteral obstruction by ligation of the left ureter; kidneys harvested 10 days after obstruction
Hydrogen-rich saline significantly reduced renal injury score, apoptosis index, interstitial fibrosis and macrophage infiltration compared with obstructed controls. It also lowered MDA and improved SOD activity, indicating reduced oxidative stress.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute carbon monoxide poisoning causing brain injury in rats
Hydrogen-rich saline given after carbon monoxide poisoning reduced neuron loss, restored antioxidant capacity, normalised myelin basic protein recognition and lowered macrophage aggregation and MIP-1-alpha and ICAM-1 expression.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute carbon monoxide poisoning causing brain injury
Hydrogen-rich saline improved cognitive deficits and reduced neuronal necrosis, apoptosis and autophagy. It decreased iron content in serum and brain and increased serum copper, suggesting reduced oxidative damage through effects on trace element metabolism.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: 45 min occlusion of the right lung root followed by 120 min reperfusion
Hydrogen-rich saline preserved pulmonary artery vasoactivity, reduced pulmonary oedema, lowered lung malondialdehyde and 8-OHdG, reduced epithelial cell apoptosis and lowered white cell count, CRP, ALT and total bilirubin.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Traumatic pancreatitis induced by controlled high pressure air impact
Intraperitoneal hydrogen-rich saline improved survival rate and histopathological findings and reduced plasma cytokine concentrations. Plasma amylase and lipase were not markedly inhibited, but pancreatic malondialdehyde fell and endogenous glutathione and superoxide dismutase were recruited.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.