Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke.
RatOtherSprague-DawleyMalen = 152 rats in total: sham 30, vehicle 63, stem cell 59; behav…Intracerebral, injected via the original needle tract at 3.5 mm depthCells suspended in 10 microlitres of phosphate-buffered sal…Six hours after induction of haemorrhage
Model: Intracerebral haemorrhage by stereotactic injection of 10 microlitres of bacterial collagenase VII (0.25 U per microlitre) into the left striatum at 1 microlitre per minute
Transplantation improved modified limb placing test scores and raised 42-day survival from 66.67 per cent with vehicle to 83.33 per cent, compared with 94.44 per cent in sham. It reduced perihaematomal neutrophil and microglial infiltration, lowered interleukin 1 beta, interleukin 6 and tumour necr…
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