Allogeneic iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury
Spinal Cord Injury
Enrolment: 60 · Results not recorded
Loading the evidence…
Biologic · Cell therapy platform; not a defined chemical entity, no ChEMBL record.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injury
Enrolment: 60 · Results not recorded
Multiple Myeloma
Enrolment: 31 · Results not recorded
Multiple System Atrophy, Parkinsonian Variant
Enrolment: 3 · Results not recorded
Acute Myeloid Leukemia
Enrolment: 10 · Results not recorded
ALS
Enrolment: 3 · Results not recorded
Diabetes
Enrolment: 100 · Results not recorded
Fibromuscular Dysplasia · Early Onset CAD
Enrolment: 34 · Results not recorded
Wilson Disease
Enrolment: 40 · Results not recorded
Depressive Disorder, Treatment-Resistant
Enrolment: 50 · Results not recorded
Turner Syndrome
Enrolment: 200 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Intracerebral haemorrhage by stereotactic injection of 10 microlitres of bacterial collagenase VII (0.25 U per microlitre) into the left striatum at 1 microlitre per minute
Transplantation improved modified limb placing test scores and raised 42-day survival from 66.67 per cent with vehicle to 83.33 per cent, compared with 94.44 per cent in sham. It reduced perihaematomal neutrophil and microglial infiltration, lowered interleukin 1 beta, interleukin 6 and tumour necr…
Extraction: extract · Supplied extraction confidence: 0.87. Machine-extracted fields require source verification.
Model: Hyperoxia-augmented ventilator-induced lung injury using high tidal volume ventilation at 30 mL/kg with room air or hyperoxia for 1 to 4 h; non-ventilated mice as controls
Intravenous induced pluripotent stem cells given one hour before ventilation reduced Src phosphorylation, oxidative stress, neutrophil influx, MIP-2 and PAI-1, microvascular leak, oedema, epithelial apoptosis and lung injury score while improving oxygenation, mirroring protection in Src-deficient m…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.