In Vivo Nanodetoxication for Acute Uranium Exposure.
MouseChemical/toxinC57BL/6Malen = 48 mice in eight groups of 6Intraperitoneal16.0 mg/kg; comparators PAMAM G5-Cou 40.0 mg/kg and EDTA 75…Immediately after uranium administration
Model: Acute uranium intoxication with a single 5.0 mg/kg dose of uranyl acetate intraperitoneally, assessed at 48 h
Uranium raised plasma urea, uric acid, creatinine and lactate dehydrogenase and caused renal tubular necrosis. Only PAMAM G4-Lys-Fmoc-Cbz protected the kidney, lowering creatinine relative to the uranium control (1.2, SD 0.17 versus 1.7, SD 0.5, p less than 0.05) and keeping lactate dehydrogenase a…
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