Other · Branched polyamidoamine polymer with Fmoc/Cbz-protected lysine surface groups; no ChEMBL entity exists for a defined-generation dendrimer, so ChEMBL was NOT queried. CLASS/MODALITY-LEVEL FLAG recorded knowingly: ClinicalTrials.gov intervention search 'PAMAM dendrimer' returned exactly 2 trials, both from one Ain Shams University dental group and both using generation-4 PAMAM with a CARBOXYLIC ACID (COOH) surface as an enamel desensitising agent. Surface chemistry differs from the Lys-Fmoc-Cbz construct and the indication (post-bleaching tooth hypersensitivity) is unrelated, so this is dendrimer-modality translation only, NOT entity translation.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Tooth Hypersensitivity
Enrolment: 60 · Results not recorded
Tooth Hypersensitivity
Enrolment: 48 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute uranium intoxication with a single 5.0 mg/kg dose of uranyl acetate intraperitoneally, assessed at 48 h
Uranium raised plasma urea, uric acid, creatinine and lactate dehydrogenase and caused renal tubular necrosis. Only PAMAM G4-Lys-Fmoc-Cbz protected the kidney, lowering creatinine relative to the uranium control (1.2, SD 0.17 versus 1.7, SD 0.5, p less than 0.05) and keeping lactate dehydrogenase a…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
